Long-term or high-dose use may cause adrenal suppression, infections, osteoporosis, cataract/glaucoma, muscle weakness, stomach ulcer/bleeding and growth retardation in children. Use with caution in diabetes, hypertension, peptic ulcer disease, osteoporosis, glaucoma, tuberculosis/latent infections, liver disease and psychiatric illness. Avoid live vaccines during therapy; report fever or signs of infection. Do not discontinue abruptly after prolonged use.