MAO inhibitors (contraindicated), alcohol and other CNS depressants (increased sedation), serotonergic drugs (SSRIs/SNRIs/triptans/linezolid) (serotonin syndrome risk), other QT-prolonging drugs and antiarrhythmics (arrhythmia risk), anticholinergics (additive side effects), opioids/tramadol (sedation/seizure risk), cimetidine (increases levels), carbamazepine/phenytoin (decreases levels), antihypertensives (may increase hypotension)